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Active substance: mercaptopurine (mercaptopurine). Pharmachologic effect: Purinethol has antitumor and immunosuppressive effects. It is a aggressive antagonist of purine bases. Indications for use: acute lymphoblastic leukemia; acute myeloid leukemia; chronic myeloid leukemia (induction of remission and maintenance therapy). Purinethol may be used both as monotherapy and in combination with other cytostatic in various doses, with respect to the therapy regimen. Usually for adults and children, the dose is 50-75 mg / m2 or 2.5 mg / kg / day; Later, daily Purinethol dosage is adjusted with regards to the effect. At first warning signs of serious leukopenia, it is recommended to interrupt the intake for 2-3 days. If leukopenia does not get worse during this period of time, the treatment is resumed. In aged people, it is advised to watch liver and kidney function. If symptoms of kidney or hepatic malfunction are discovered, the dose must be decreased. The the dose should also be lowered for patients with hepatic and / or renal insufficiency.When coupled with allopurinol, the dosage of Mercaptopurine is lowered to 25% of the regular dose, since allopurinol cuts down on metabolic rate of Mercaptopurine. Purchase Purinethol without prescription on line at the greatest selling price. Unwanted side effects. From the side of hematopoiesis: very often - leukopenia, thrombocytopenia, anemia. Reactions from the body's defense mechanisms: hypersensitivity reactions: seldom - arthralgia, skin rash, drug fever; hardly ever - inflammation. On the digestive system part: often - nausea, throwing up, anorexia, intrahepatic cholestasis, hepatotoxicity (hepatotoxicity has a toxic-allergic genesis and occurs when the advised dosage of 2.5 mg / kg / day or 75 mg / m2 / day is exceeded; almost never - ulceration of the oral mucosa, diarrhea, pancreatitis, hepatonecrosis; hardly ever - ulceration of the intestinal mucosa. Other: lowered immunity, accession of secondary bacterial infections, skin hyperpigmentation; hyperuricemia and nephropathy due to tumor lysis; very rarely - the introduction of secondary leukemia, myelodysplasia and hepatolienal T-cell lymphoma. Click the link for More details on Purinethol France and very best spot to buy 24x7pharmacie.com/purinethol/
Contraindications for use are the following: pregnant state; lactation period, allergic reaction to Mercaptopurine or other components in the drug. Over dose symptoms: immediate - nausea, vomiting, anorexia, diarrhea; postponed - myelosuppression, hardworking liver dysfunction, gastroenteritis. Special recommendations! Purinethol needs to be used only under doctor’s guidance and the doctor should have experience in the use of cytostatics. Therapy should be carried out under health-related guidance. Do not wait to follow the web page link for more information about Mercaptopurine France and very best internet site to buy Purinethol Without Prescription for affordable.